Phenyl peptides, method for preparing same, and pharmaceutical compositions containing said peptides

Abstract

The present invention relates to synthetic peptides containing as least nine amino acids of formula (I): ##STR1## in which X and Y are protected or unprotected amino acid residues, or peptides R is a linear or branched alkyl radical R" is one of the following radicals: alkyl, phenyl, halogen, nitro, amino, alkyl amino, alkoxy, trifluoromethyl, trifluoromethoxy, carboxamido or cyano Z is a sulphur, an oxygen, an amino or a sulphoxide and n is equal to 0, 1, 2 or 3. The compounds of formula I are inhibitors of HIV replication by acting as inhibitors of a small aspartyl-protease dimer which specifically cleaves the precursors of a polyprotein coding for the structural proteins and the constitutive enzymes of the HIV virus.

Dependencies are inferred from the claim text.