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US 5,844,017 AGranted
Prepolymers of absorbable polyoxaesters containing amines and/or amido groups
AssigneeEthicon, Inc.
InventorsDennis D. Jamiolkowski, Rao S. Bezwada
Life of this patent
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Abstract
The present invention describes a prepolymer of aliphatic polyoxaesters containing amines and/or amido groups having polymerizable end groups that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like.
Claims19
A prepolymer comprising an aliphatic polyoxaester having a first divalent repeating unit of formula I:
- O--C(O)--C(R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1) (R.sub.2)--C(O)--! I
- and a second repeating unit selected from the group of formulas consisting of:
- --O--R.sub.12 --!.sub.U, XIV
- wherein R.sub.1 and R.sub.2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
- R.sub.3 is an alkylene unit or is an oxyalkylene group of the following formula:
- --(CH.sub.2).sub.C --O--!.sub.D --(CH.sub.2).sub.E -- IV
- wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12;
- R.sub.12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R.sub.10)--) or amide (--N(R.sub.11)--);
- R.sub.10 and R.sub.11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms;
- and U is an integer in the range of from 1 to about 2,000;
- wherein the aliphatic polyoxaester is chemically linked to a polymerizable region.
8 more elements
Dependencies are inferred from the claim text.