Cyclopropachromencarboxylic acid derivatives
AssigneeSuntory Limited
InventorsHirokazu Annoura, Atsuko Fukunaga, Toshio Tatasuoka, Yoshiko Horikawa
Life of this patent
Estimating the term…
Loading patent…
AssigneeSuntory Limited
InventorsHirokazu Annoura, Atsuko Fukunaga, Toshio Tatasuoka, Yoshiko Horikawa
Estimating the term…
The present invention provides novel cyclopropachromen-carboxylic acid derivatives having an antagonistic activity against metabotropic glutamate receptors and its pharmaceutically acceptable salts. Cyclopropachromen-carboxylic acid derivatives and its pharmaceutically acceptable salts represented by the following general formula (1): ##STR1## wherein A denotes an oxygen atom, hydroxyimino group, an alkyloxyimino group having 1 to 5 carbon atoms, or the group .dbd.N--O--(CH.sub.2).sub.n -NR.sup.1 R.sup.2 (where n represents an integer of 2 to 8, and each of R.sup.1 and R.sup.2 independently represents a hydrogen atom or alkyl group having 1 to 5 carbon atoms, respectively); B denotes the group --COOR.sup.3 (where R.sup.3 represents a hydrogen atom or alkyl group having 1 to 5 carbon atoms) or the group --CONR.sup.4 R.sup.5 (where R.sup.4 and R.sup.5 independently represent a hydrogen atom, alkyl group having 1 to 5 carbon atoms, alkenyl group having 2 to 5 carbon atoms and an aminoalkyl group.
A cyclopropachromencarboxylic acid derivative and its pharmaceutically acceptable salts represented by the following formula (I):
Dependencies are inferred from the claim text.