Diphenylethane compounds containing a saturated heterocyclic group, their preparation, and their therapeutic use

A compound of formula (I):

• ##STR5## wherein:
• R.sup.1 represents a saturated heterocyclic group attached to the bond or group represented by A through a ring carbon atom, said saturated heterocyclic group having from 3 to 6 ring atoms, of which one or two are hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur hetero-atoms, and being substituted on at least one carbon atom by at least one substituent selected from the group consisting of substituents .alpha. defined below or being unsubstituted on a nitrogen atom or being substituted on a nitrogen atom by at least one substituent selected from the group consisting of substituents .beta. defined below;
• R.sup.2a and R.sup.2b are the same as or different from each other and each represents a hydrogen atom, a fluorine atom or a chlorine atom and R.sup.2c is a hydrogen atom, wherein at least one of R.sup.2a and R.sup.2b is not a hydrogen atom;
• R.sup.3a, R.sup.3b, R.sup.3c and R.sup.3d are the same as or different from each other and each represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a haloalkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, an alkynyl group having from 2 to 6 carbon atoms, a hydroxy group, an alkoxy group having from 1 to 6 carbon atoms, a haloalkoxy group having from 1 to 6 carbon atoms, an alkoxycarbonyloxy group having from 2 to 6 carbon atoms, an alkanoyloxy group having from 1 to 6 carbon atoms, a carbamoyloxy group, an alkylcarbamoyloxy group in which the alkyl part has from 1 to 6 carbon atoms, a dialkylcarbamoyloxy group in which each alkyl part has from 1 to 6 carbon atoms, a halogen atom, a cyano group, a nitro group or an aryl group as defined below;
• A represents a single bond or an alkylene group having from 1 to 6 carbon atoms;
• said substituents .alpha. are selected from the group consisting of hydroxy groups, alkoxycarbonyloxy groups in which the alkoxy part has from 1 to 20 carbon atoms, alkanoyloxy groups having from 1 to 20 carbon atoms, alkanoyloxy groups having from 2 to 7 carbon atoms and substituted by a carboxy group, carbamoyloxy groups, alkylcarbamoyloxy groups having from 1 to 6 carbon atoms, and dialkylcarbamoyloxy groups in which each alkyl part has from 1 to 10 carbon atoms;
• said substituents .beta. are selected from the group consisting of alkyl groups having from 1 to 6 carbon atoms, alkyl groups having from 1 to 6 carbon atoms and substituted by at least one aryl group as defined below, aryl groups as defined below, and alkoxycarbonyl groups having from 2 to 10 carbon atoms;
• said aryl groups are carbocyclic aromatic groups which have from 6 to 10 ring carbon atoms and which are unsubstituted or are substituted by at least one substituent selected from the group consisting of substituents .gamma., defined below;
• said substituents .gamma. are selected from the group consisting of alkyl groups having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms, and halogen atoms;
• or pharmaceutically acceptable salts or esters thereof.