1, 1-BIS (heteroazolyl) alkane derivatives and their use as neuroprotective agents

A pharmaceutical formulation containing a compound having the general formula (1) ##STR36## wherein:

• X.sub.1 and X.sub.2 are independently O, S or Se;
• Y.sub.1 and Y.sub.2 are independently C or N with the proviso that at least one of Y.sub.1 and Y.sub.2 is N;
• Y.sub.3 and Y.sub.4 are independently C or N with the proviso that at least one of Y.sub.3 and Y.sub.4 is N;
• R.sub.1 and R.sub.2 each represent one or more groups independently selected from H, lower alkyl, lower alkoxy-lower alkyl, hydroxy-lower alkyl, lower acyloxy-lower alkyl or CF.sub.3 ;
• and A is ##STR37## wherein W is O, S, NH or N-lower alkyl, R.sub.3 is H, lower alkyl or lower acyl,
• or WR.sub.3 is H,
• R.sub.4 is lower alkyl or lower perfluoroalkyl,
• or R.sub.3 and R.sub.4 together form a ring ##STR38## wherein n is 2, 3 or 4, R.sub.5 and R.sub.6 independently are H or lower alkyl;
• geometrical and optical isomers and racemates thereof where such isomers exist, as well as pharmaceutically acceptable acid addition salts thereof and solvates thereof,
• as active ingredient and a pharmaceutically acceptable carrier.