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US 5,843,965 AGranted
Benzo B! thiophene compounds, intermediates, processes, compositions, and methods
AssigneeEli Lilly and Company
InventorAlan David Palkowitz
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Abstract
The instant invention provides novel benzob!thiophene compounds, intermediates, compositions, pharmaceutical formulations, and methods of use for the inhibition of bone loss or bone resorption and for treatment of cardiovascular-related pathological conditions.
Claims1
A compound of formula I ##STR29## wherein R.sup.1 is --H, --OH, --O(C.sub.1 -C.sub.4 alkyl), --OCOAr where Ar is phenyl or substituted phenyl, --O(CO)OAr where Ar is phenyl or substituted phenyl, --OCO(C.sub.1 -C.sub.6 alkyl), --O(CO)O(C.sub.1 -C.sub.6 alkyl), or --OSO.sub.2 (C.sub.4 -C.sub.6 alkyl);
- R.sup.2 is methoxy;
- R.sup.3 is fluoro;
- R.sup.4 is --H, --F, --Cl, --CH.sub.3, --OH, --O(C.sub.1 -C.sub.4 alkyl), --OCOAr where Ar is phenyl or substituted phenyl, --OCO(C.sub.1 -C.sub.6 alkyl), --O(CO)O(C.sub.1 -C.sub.6 alkyl), or --OSO.sub.2 (C.sub.4 -C.sub.6 alkyl);
- n is 2 or 3;
- and
- R.sup.5 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino;
- or a pharmaceutically acceptable salt or solvate thereof.
4 more elements
Dependencies are inferred from the claim text.