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US 5,843,960 AGranted
Inhibitors of rotamase enzyme activity
AssigneesGPI NIL Holdings, Inc., The Johns Hopkins University School of Medicine
InventorsJoseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
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Abstract
This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
Claims6
A method for preventing neurodegenerative effects of a neurological disorder in an animal in need thereof, comprising:
- administering to an animal an effective amount of a nonimmunosuppressive pipecolic acid derivative having an affinity for FKBP-type immunophilins to prevent neurodegeneration, wherein the FKBP-type immunophilin exhibits rotamase activity and the nonimmunosuppressive pipecolic acid derivative inhibits said rotamase activity of the immunophilin.
Dependencies are inferred from the claim text.