Methods and bicyclic polyamine compositions for the treatment of inflammation
AssigneeUniversity of Florida Research Foundation, Inc.
InventorRaymond J. Bergeron, Jr.
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Abstract
Methods for treating inflammatory conditions wherein the active agent is a polyamine having the formula set forth below: ##STR1## or a salt thereof with a pharmaceutically acceptable acid wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and represent H, straight- or branched-chain alkyl, aryl, aryl alkyl or cycloalkyl of 1-12 carbon atoms; a, b, c and d may be the same or different and are integers from 0 to 8, except that when a or c is zero, b or d is greater than or equal to 3 and when a or c is one, b or d is greater than or equal to 2; and X, Y and Z may be the same or different; X and Z are integers from 0 to 10; and Y is an integer from 1 to 10, excluding the polyamine of the formula wherein a=b=c=d=2, X=Z=2 and Y=4.
Claims4
A method for treating inflammation in a human or non-human mammal suffering therefrom comprising administering to said mammal an amount of a polyamine or a pharmaceutically acceptable acid salt thereof sufficient to exert an anti-inflammatory activity in said mammal, said polyamine having the formula:
- ##STR3## or a salt thereof with a pharmaceutically acceptable acid wherein:
- R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and represent H, straight- or branched-chain alkyl, aryl, aryl alkyl or cycloalkyl of 1-12 carbon atoms;
- a, b, c and d may be the same or different and are integers from 0 to 8, except that when a or c is zero, b or d is greater than or equal to 3 and when a or c is one, b or d is greater than or equal to 2;
- and
- X, Y and Z may be the same or different;
- X and Z are integers from 0 to 10;
- and Y is an integer from 1 to 10, excluding the polyamine of the formula wherein a=b=c=d=2, X=Z=2 and Y=4.
Dependencies are inferred from the claim text.