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US 5,843,958 AGranted
Arylpyrazoles as leukotriene inhibitors
AssigneeOrtho Pharmaceutical Corporation
InventorsMichael P. Ferro, Michael P. Wachter
Life of this patent
Estimating the term…
Abstract
Compounds of Formula I ##STR1## useful in the treatment of inflammatory disorders.
Claims9
A compound selected from those of Formula I ##STR24## wherein:
- R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are selected from the group consisting of hydrogen, C.sub.1-5 alkyl, C.sub.1-5 alkoxy, phenyl, halo, hydroxy, C.sub.1-5 alkylsulfonyl, C.sub.1-5 alkylthio, trihaloC.sub.1-5 alkyl, amino, nitro and 2-quinolinylmethoxy;
- R.sub.5 is selected from the group consisting of C.sub.1-5 alkyl and R.sub.7 where R.sub.7 is (CH.sub.2).sub.n R.sub.8 or (CH.sub.2).sub.n CHR.sub.8 R.sub.9 where
- n is 1 or 2;
- R.sub.8 is halo, oxy, carbonyl, hydroxy, oximino, carboxy, C.sub.1-5 alkoxycarbonyl, N--C.sub.1-5 alkyl-N-hydroxy-amido;
- R.sub.9 is 4-(2-quinolinylmethoxy)phenyl;
- R.sub.6 is selected from the group consisting of hydrogen, C.sub.1-5 alkyl and halo;
- with the proviso that if R.sub.9 is present, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are other than 2-quinolinylmethoxy;
- with the further proviso that if R.sub.9 is absent one of R.sub.1, R.sub.2, R.sub.3, and R.sub.4 is 2-quinolinylmethoxy;
- and pharmaceutically acceptable salts thereof.
6 more elements
Dependencies are inferred from the claim text.