Naphthyridine derivatives
AssigneeSumitomo Pharmaceuticals Company, Limited
InventorsMasami Muraoka, Katsuhisa Ioriya, Naohito Ohashi, Hideki Yagi
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Abstract
Naphthyridine derivative of the formula: ##STR1## wherein Ring A is substituted or unsubstituted pyridine, X is --N(R.sup.2)--CO--(R.sup.2 is H, alkyl, substituted alkyl, etc.), Z is a direct bond, --NH--, C.sub.1 -C.sub.2 alkylene, or --CH.dbd.CH--, Y is alkyl, substituted alkyl, aromatic group or substituted aromatic group, etc., B is alkyl, substituted alkyl, aromatic group or substituted aromatic group, or an acid addition salt thereof, these compounds having acyl-CoA: cholesterol acyl transferase inhibitory activity, and being useful as an agent for prophylaxis or treatment of hyperlipidemia, atherosclerosis, and related diseases thereof.
Claims22
A naphthyridine derivative of the formula:
- ##STR228## wherein Ring A is a substituted or unsubstituted pyridine ring, X is a group of the formula:
- ##STR229## wherein R.sup.2 is a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an alkynyl group, a substituted alkynyl group, a cycloalkyl group, or a substituted cycloalkyl group, or a group of the formula:
- ##STR230## wherein W is a hydrogen atom or a group:
- --OR.sup.1 (R.sup.1 is an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an alkynyl group, or a substituted alkynyl group),
- Z is a direct bond, --NH--, an alkylene group having 1 to 2 carbon atoms, or --CH.dbd.CH--,
- Y is an alkyl group, a substituted alkyl group, a cycloalkyl group, a substituted cycloalkyl group, an aromatic group or a substituted aromatic group,
- B is an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, a cycloalkyl group, a substituted cycloalkyl group, an aromatic group, or a substituted aromatic group, or an acid addition salt thereof.
Dependencies are inferred from the claim text.