AMPA antagonists and a method of treatment
AssigneeNeuroSearch A/S
InventorsFrank Watjen, Jorgen Drejer
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Abstract
The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl or benzyl; X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl or benzyl; Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH or alkyl; n is 0 or 1; R.sup.6 is phenyl, naphthyl, thienyl, pyridyl, all of which may be substituted one or more times with substituents selected from the group consisting of halogen, CF.sub.3, NO.sub.2, amino, alkyl, alkoxy and phenyl; A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b. The compounds are useful in the treatment of cerebrovascular disorders. ##STR1##
Claims11
A compound selected from those having the formula ##STR22## and a pharmaceutically-acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl, or benzyl;
- X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl, or benzyl;
- Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH, or alkyl;
- n is 1;
- R.sup.6 is
- phenyl,
- naphthyl,
- thienyl, or
- pyridyl,
- all of which may be substituted one or more times with a substituent selected from the group consisting of halogen, CF.sub.3, NO.sub.2, amino, alkyl, alkoxy, and phenyl;
- A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b, and formed by one of the following bivalent radicals:
- a-NR.sup.12 --CH.sub.2 --CH.sub.2 -b
- a-CH.sub.2 --CH.sub.2 --NR.sup.12 -b
- a-CH.sub.2 --NR.sup.12 --CH.sub.2 -b,
- a-CH.sub.2 --CH.sub.2 --NR.sup.12 --CH.sub.2 -b,
- a-CH.sub.2 --NR.sup.12 --CH.sub.2 --CH.sub.2 -b,
- a-CH.sub.2 --CH.sub.2 --CH.sub.2 --NR.sup.12 -b,
- a-NR.sup.12 --CH.sub.2 --CH.sub.2 --CH.sub.2 -b,
- a-CH.sub.2 --CH.sub.2 --NR.sup.12 --CH.sub.2 --CH.sub.2 -b,
- a-CH.sub.2 --CH.sub.2 --CH.sub.2 --NR.sup.12 --CH.sub.2 -b,
- a-CH.sub.2 --NR.sup.12 --CH.sub.2 --CH.sub.2 --CH.sub.2 -b,
- a-CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --NR.sup.12 -b, and
- a-NR.sup.12 --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 -b,
- wherein
- R.sup.12 is hydrogen, CH.sub.2 CH.sub.2 OH, or alkyl.
Dependencies are inferred from the claim text.