Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
AssigneeAmerican Cyanamid Company
InventorsJoseph M. Backer, Peter Bohlen
Life of this patent
Estimating the term…
Abstract
The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of a 7-substituted amino!-9-(substituted glycyl)amido!-6-demethyl-6-deoxytetracycline of Formula I: ##STR1## wherein R, R.sub.2, R.sub.3, and W are as defined in the specification. The invention also relates to a method for inhibiting proliferation of tumor cells and tumor growth by administering an inhibitory amount of a compound of Formula I in combination with a chemotherapeutic agent or radiation therapy. The invention also relates to compositions containing an effective inhibitory amount of a compound of Formula I in a pharmaceutically acceptable carrier.
Claims16
A method for inhibiting angiogenesis and endothelial cell proliferation which comprises administering an effective inhibitory amount of a compound of formula I:
- ##STR9## wherein R is a (disubstituted) amino of the formula --N(R.sub.4)(R.sub.5) and (R.sub.4)and (R.sub.5) may be the same or different and are selected from straight or branched (C.sub.1 -C.sub.4)alkyl, or (C.sub.3 -C.sub.6)cycloalkyl!(C.sub.1 -C.sub.4)alkyl;
- W is (R.sub.1).sub.2 --N--;
- R.sub.1 --NH-- or (C.sub.2 -C.sub.5)azacycloalkane wherein
- R.sub.1 is a straight chain (C.sub.1 -C.sub.7)alkyl;
- R.sub.2 is hydrogen or (C.sub.1 -C.sub.3)alkyl;
- R.sub.3 is hydrogen or (C.sub.1 -C.sub.3)alkyl;
- or a pharmaceutically acceptable salt thereof;
- alone or in combination with a therapeutic agent used in the treatment of an angiogenic disorder;
- to a warm blooded animal having a disorder characterized by the undesired proliferation of endothelial cells.
A composition for inhibiting angiogenesis and endothelial cell proliferation which composition comprises an amount effective for inhibiting endothelial cell proliferation of a compound of formula I:
- ##STR10## wherein R is a disubstituted amino of the formula --N(R.sub.4)(R.sub.5) and (R.sub.4)and (R.sub.5) may be the same or different and are selected from straight or branched (C.sub.1 -C.sub.4)alkyl, or (C.sub.3 -C.sub.6)cycloalkyl!(C.sub.1 -C.sub.4)alkyl;
- W is (R.sub.1).sub.2 --N--;
- R.sub.1 --NH-- or (C.sub.2 --C.sub.5)azacycloalkane wherein
- R.sub.1 is a straight chain (C.sub.1 -C.sub.7)alkyl;
- R.sub.2 is hydrogen or (C.sub.1 -C.sub.3)alkyl;
- R.sub.3 is hydrogen or (C.sub.1 -C.sub.3)alkyl;
- or a pharmaceutically acceptable salt thereof;
- in a pharmaceutical carrier for administration to a warm blooded animal having a disorder characterized by the uncontrolled proliferation of endothelial cells.
Dependencies are inferred from the claim text.