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US 5,843,917 AGranted
5-Fluorouracil derivatives
AssigneeGlaxo Wellcome Inc.
InventorsFrank Leslie Boyd, Thomas Anthony Krenitsky
Life of this patent
Estimating the term…
Abstract
Novel compounds comprising 5-fluorouracil or 5-fluorouridine covalently linked to 5-ethynyluracil, 5-ethynyluridine or 5-propynyluracil and pharmaceutical compositions comprising such compounds are disclosed.
Claims3
A compound selected from:
- 5-ethynyl-5"-fluoro-3',3'"-O-succinylbis-(1-(2-deoxy-.beta.-D-erythropento furanosyl)uracil);
- 5-ethynyluridine-5-fluoro-1-(.beta.-D-arabinofuranosyl)uracil succinic acid 5',2'-diester;
- 5-fluoro-5"-(1-propynyl)-2',2'"-O-succinylbis(1-.beta.-D-arabinofuranosyl)u racil);
- and
- 5-chloro-2'-5'-dideoxy-5-fluorouridine-2'"-deoxy-5"-ethynyluridine (3'-5'")diphosphate.
2 more elements
A pharmaceutical composition comprising a compound selected from:
- 5-ethynyl-5"-fluoro-3',3'"-O-succinylbis-(1-(2-deoxy-.beta.-D-erythropento furanosyl)uracil);
- 5-ethynyluridine-5-fluoro-1-(.beta.-D-arabinofuranosyl)uracil succinic acid 5',2'-diester;
- 5-fluoro-5"-(1-propynyl)-2',2'"-O-succinylbis(1-.beta.-D-arabinofuranosyl)u racil);
- and
- 5-chloro-2'-5'-dideoxy5-fluorouridine 2'"-deoxy-5'"-ethynyluridine (3'-5'")diphosphate
- together with one or more pharmaceutically acceptable carriers.
3 more elements
Dependencies are inferred from the claim text.