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US 5,843,901 AGranted
LHRH antagonist peptides
AssigneeAdvanced Research and Technology Institute, Inc.
InventorRoger W. Roeske
Life of this patent
Estimating the term…
Abstract
Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed.
Claims5
A peptide compound comprising a structure:
- A-B-C-D-E-F-G-H-I-J
- wherein
- A is pyro-Glu, Ac-D-Nal, Ac-D-Qal, Ac-Sar, or Ac-D-Pal;
- B is His or 4-Cl-D-Phe;
- C is Trp, D-Pal, D-Nal, L-Nal-D-Pal(N-O), or D-Trp;
- D is Ser;
- E is N-Me-Ala, Tyr, N-Me-Tyr, Ser, Lys(iPr), 4-Cl-Phe, His, Asn, Met, Ala, Arg or Ile;
- F is D-Asn or D-Gln;
- G is Leu or Trp;
- H is Lys(iPr), Gln, Met, or Arg;
- I is Pro;
- and
- J is Gly-NH.sub.2 or D-Ala-NH.sub.2 ;
- or a pharmaceutically acceptable salt thereof.
11 more elements
A peptide compound comprising a structure:
- A-B-C-D-E-F-G-H-I-J
- wherein
- A is pyro-Glu, Ac-D-Nal, Ac-D-Qal, Ac-Sar, or Ac-D-Pal;
- B is His or 4-Cl-D-Phe;
- C is Trp, D-Pal, D-Nal, L-Nal-D-Pal(N-O), or D-Trp;
- D is Ser;
- E is N-Me-Ala, Tyr, N-Me-Tyr, Ser, Lys(iPr), 4-Cl-Phe, His, Asn, Met, Ala, Arg or Ile;
- F is D-Asn;
- G is Leu or Trp;
- H is Lys(iPr), Gln, Met, or Arg;
- I is Pro;
- and
- J is Gly-NH.sub.2 or D-Ala-NH.sub.2 ;
- or a pharmaceutically acceptable salt thereof.
11 more elements
A peptide compound comprising a structure:
- Ac-D-Nal-4-Cl-D-Phe-D-Pal-Ser-N-Me-Tyr-D-Asn-Leu-Lys(iPr)-Pro-D-Ala-NH.sub. 2 ;
- or a pharmaceutically acceptable salt thereof.
A peptide compound comprising a structure:
- Ac-D-Nal-4-Cl-D-Phe-D-Pal-Ser-Tyr-D-Asn-Leu-Lys(iPr)-Pro-D-Ala-NH.sub.2 ;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.