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US 5,843,895 AGranted
Pharmaceutical administration of ecotin homologs
AssigneeGenentech, Inc.
InventorsRobert A. Lazarus, Mark S. Dennis, Jana Seymour Ulmer
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Abstract
A potent serine protease inhibitor capable of inhibiting Factor Xa, Factor XIIa, plasma kallikrein, and human leukocyte elastase is provided. The inhibitor is provided in a pharmaceutical composition for treatment of diseases where inhibition of Factor Xa, Factor XIIa, plasma kallikrein, or HLE is indicated.
Claims6
A method for inhibiting thrombus formation in a mammal comprising administering a pharmaceutically effective amount of a composition comprising a homolog of ecotin which inhibits Factor Xa which homolog is represented by formula IV
- R.sup.1 -Ser-Thr-P.sup.1 -Met-Ala-Cys-R.sup.2 (SEQ ID NO:
- 4)IV
- where
- P.sup.1 is selected from the group consisting of Arg, Lys, Ala, Asp, and Glu;
- R.sup.1 represents amino acid residues 1-81 of ecotin;
- R.sup.2 represents amino acid residues 88-142 of ecotin and a pharmaceutically acceptable excipient to the mammal.
3 more elements
Dependencies are inferred from the claim text.