Methods for reduced renal uptake of antibody fragments
AssigneeCenter for Molecular Medicine and Immunology
InventorsThomas M. Behr, David M. Goldenberg
Life of this patent
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Abstract
Kidney uptake of antibody fragment conjugates in patients is reduced by administration to the patient of one or more compounds selected from the group consisting of D-lysine, poly-D-lysine, or poly-L-lysine, or pharmaceutically acceptable salts or carboxyl derivatives thereof.
Claims12
A method of reducing kidney retention of antigen binding antibody fragment conjugates in a patient during radioimmunodiagnosis or immunotherapy, comprising administering to said patient an effective amount of one or more compounds selected from the group consisting of D-lysine molecule, poly-lysine molecule and pharmaceutically acceptable salts thereof,
- wherein the poly-lysine molecule and the pharmaceutically acceptable salts thereof comprise poly-D-lysine or poly-L-lysine and have a molecular weight in the range of 1-60 kDa,
- whereby said compound or compounds reduce kidney retention of said antibody fragment conjugates.
Dependencies are inferred from the claim text.