Stimulation of nerve growth and/or vitality
AssigneeCalifornia Institute of Technology
InventorPaul H. Patterson
Life of this patent
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Abstract
The protein, cholinergic neuronal differentiation factor (CDF), also known as leukemia inhibitory factor (LIF), is described, together with the use of the polypeptide to stimulate neuron growth and survival in animals either by direct administration or by autotransplantation of adrenal medullary cells converted to the cholinergic phenotype.
Claims3
A method for ameliorating a disease state associated with acetylcholine deficiency, comprising administering cholinergic neuronal differentiation factor/leukemia inhibitory factor (CDF/LIF) to an animal, to adrenal medullary chromaffin cells, or to injured nerves, in an amount effective to stimulate neuronal acetylcholine synthesis.
The method comprising the administration of an effective amount of a polypeptide to animals to stimulate neuronal acetylcholine synthesis wherein the polypeptide includes the following amino acid sequence:
- ______________________________________ MetLysValLeuAlaAlaGlyIleValProLeuLeuLeuIleLeuHis TrpLysHisGlyAlaGlySerProLeuProIleThrProValAsnAlaThr CysAlaIleArgHisProCysHisGlyAsnLeuMetAsnGlnIleLysSer GlnLeuAlaGlnLeuAsnGlySerAlaAsnAlaLeuPheIleSerTyrTyr ThrAlaGlnGlyGluProPheProAsnAsnValAspLysLeuCysAlaPro AsnMetThrAspPheProProPheHisAlaAsnGlyThrGluLysThrLys LeuValGluLeuTyrArgMetValAlaTyrLeuGlyAlaSerLeuThrAsn IleThrTrpAspGlnLysAsnLeuAsnProThrAlaValSerLeuGlnIle LysLeuAsnAlaThrThrAspValMetArgGlyLeuLeuSerAsnValLeu CysArgLeuCysAsnLysTyrHisValGlyHisValAspValProCysVal ProAspAsnSerSerLysGluAlaPheGlnArgLysLysLeuGlyCysGln LeuLeuGlyThrTyrLysGlnValIleSerValValValGlnAlaPhe. ______________________________________
Dependencies are inferred from the claim text.