Compositions for delivery of polypeptides, and methods
AssigneeAllied Medical Research Associates
InventorsSerge Petit, Emile Bourland, deceased
Life of this patent
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Abstract
Compositions comprising intrinsic factor (IF), and in particular, compositions comprising substantially pure intrinsic factor (IF) and a polypeptide wherein said composition is substantially free of R protein; a method of delivering a composition to the portal and/or lymphatic circulation system of a host; and a method of producing the above-described composition.
Claims6
A method of delivering an insulin-containing composition to the circulation system of a host in need of insulin comprising:
- administering orally to said host a pharmaceutical composition comprising:
- a) substantially pure intrinsic factor (IF),
- b) insulin, and
- c) a physiologically acceptable carrier, diluent, excipient or adjuvant;
- wherein said composition is substantially free of R protein, wherein said IF is non covalently bound to said insulin, and wherein after oral administration, said insulin enters the circulation system.
A pharmaceutical composition comprising substantially pure intrinsic factor(IF) non covalently bound to insulin, together with a physiologically acceptable carrier, diluent, excipient or adjuvant, wherein said composition is substantially free of R protein.
Dependencies are inferred from the claim text.