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US 5,843,776 AGranted
Method of expressing genes in mammalian cells
AssigneeUniversity Technologies International Inc.
InventorsTaiki Tamaoki, Hidekazu Nakabayashi
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Abstract
The present invention relates to a method of expressing a heterologous gene in mammalian cells and a recombinant DNA construct for use in the method. The invention also relates to a method of specifically killing cells which constitutively express AFP.
Claims12
An isolated silencer region comprising the silencer sd mutant sequence in FIG. 14 (SEQ ID NO:25).
An isolated nucleic acid sequence comprising at least six copies of a human AFP silencer region and at least one copy of a promoter sequence functionally linked to a direct toxin gene.
Dependencies are inferred from the claim text.