Human dorsal tissue affecting factor (noggin) and nucleic acids encoding same
AssigneesRegeneron Pharmaceuticals, Inc., The Regents of the University of California
InventorsDavid M. Valenzuela, Nancy Y. Ip, Henryk D. Cudny, George D. Yancopoulos, Richard M. Harland, William C. Smith, Teresa Lamb, Anne Knecht
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Abstract
Novel dorsal growth inducing factors, complexes including the factors, and DNA or RNA coding sequences for the factors are described.
Claims23
An isolated nucleic acid molecule having a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence comprising the coding region of human noggin contained in the vector designated as hnogX-9 (ATCC Accession No. 75310);
- and
- (b) a nucleotide sequence differing from the sequence of (a) and which encodes a polypeptide encoded by the sequence of (a).
An isolated nucleic acid molecule having a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence comprising the coding region of human noggin as set forth in SEQ ID No.1;
- and
- (b) a nucleotide sequence differing from the sequence of (a) and which encodes a polypeptide encoded by the sequence of (a).
An isolated nucleic acid molecule encoding human noggin having the amino acid sequence as depicted in SEQ ID No.2.
Isolated human noggin encoded by a nucleotide sequence comprising the nucleotide sequence as set forth in SEQ. ID. NO.1.
Isolated human noggin comprising the amino acid sequence as set forth in SEQ ID No.2.
Dependencies are inferred from the claim text.