Antisense constructs directed against viral post-transcriptional regulatory sequences
AssigneeThe Immune Response Corporation
InventorsCharles R. Ill, Jose E. N. Gonzales
Life of this patent
Estimating the term…
Abstract
Antisense constructs ditrected against viral cis-acting post-transcriptional regulatory sequences ("PREs") are disclosed. In one embodiment, the antisense construct is an expression plasmid encoding one or more antisense transcripts which hybridize under intracellular conditions to all or a portion of a viral PRE within a viral transcript, the PRE having the function of directing export of the viral transcript from the nucleus to the cytoplasm of a cell. The antisense constructs can be used to inhibit viral production, such as HBV production.
Claims11
A vector encoding one or more antisense transcripts which are complementary to all or a portion of a hepatitis B viral cis-acting post-transcriptional regulatory element, said post-transcriptional regulatory element comprising the nucleotide sequence shown in SEQ ID NO:1 and having the function of directing export of the viral transcript from the nucleus to the cytoplasm of a cell.
Dependencies are inferred from the claim text.