Ehk and Ror tyrosine kinases
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsPeter C. Maisonpierre, Piotr Masiakowski, George D. Yancopoulos
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Abstract
The present invention provides for novel receptor tyrosine kinases known as Ror-1, Ror-2, Ehk-1 and Ehk-2. The invention also provides for assay systems that may be used to detect and/or measure neurotrophin activity or to identify agents that exhibit neurotrophin-like activity. It is based, at least in part, on the discovery that the trkB proto-oncogene encodes a tyrosine kinase receptor that may serve as a functional binding protein for BDNF and NT-3. The present invention also provides for diagnostic and therapeutic methods based on the interaction between BDNF and/or NT-3 and trkB.
Claims8
An isolated and purified nucleic acid molecule comprising ror1, wherein the sequence of said nucleic acid is selected from the group consisting of:
- (a) the sequence of the DNA comprising the coding region of the ror1 DNA sequence contained in the plasmid pBluescript SK-containing Rtk-2 as deposited with the American Type Culture Collection on Jul. 24, 1991 and designated as 75052;
- and (b) DNA sequences that are degenerate as a result of the genetic code to a DNA sequence of (a).
An isolated and purified nucleic acid molecule comprising ror2 wherein the sequence of said nucleic acid is selected from the group consisting of:
- (a) the sequence of the DNA comprising the coding region of the ror2 DNA sequence contained in the plasmid pBluescript SK-containing Rtk-3 as deposited with the American Type Culture Collection on Jul. 24, 1991 and designated as 75053;
- and (b) DNA sequences that are degenerate as a result of the genetic code to a DNA sequence of (a).
An isolated and purified nucleic acid molecule comprising ehk 1, wherein the sequence of said nucleic acid is selected from the group consisting of:
- (a) the sequence of the DNA comprising the coding region of the ehk 1 DNA sequence set forth in FIG. 22A (SEQ ID NO:
- 102);
- and (b) DNA sequence that are degenerate as a result of the genetic code to a DNA sequence of (a).
An isolated and purified nucleic acid molecule comprising ehk 2 wherein the sequence of said nucleic acid is selected from the group consisting of:
- (a) the sequence of the DNA comprising the coding region of the ehk 2 DNA sequence set forth in FIG. 21 (SEQ ID NO:
- 100);
- and
- (b) DNA sequences that are degenerate as a result of the genetic code to a DNA sequence of (a).
Dependencies are inferred from the claim text.