Cancer associated gene protein expressed therefrom and uses thereof
OwnerLan Bo Chen, Shideng Baoinventors
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Abstract
We have now discovered that eukaryotes, including mammals, have a gene that encodes a multifunctional protein having helicase activity, DNA repair activity, p53 sequestering activity and oncogenetic transformation potential. Enhanced transcripts and expression of this gene in non-testicular cells have a high correlation to disease state in a number of cancers, such as colorectal carcinomas, hereditary cancers resulting from defects in DNA repair pathways, breast cancers, etc. Accordingly, discovering enhanced levels of transcript or gene product in non-testicular tissues can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer.
Claims13
An isolated nucleotide sequence encoding a human TAH protein having an amino acid sequence as set forth in SEQ ID:No.2, or an allelic variation thereof, and having helicase and p53 binding activity.
An isolated nucleotide sequence having the sequence as set forth in SEQ ID NO:1.
An isolated nucleotide sequence having the complementary sequence of SEQ ID NO:
- 1.
An isolated nucleotide sequence having nucleotides 495-518, 1140-1154, 1191-1205 or 1306-1332 of SEQ ID:No.1.
An isolated nucleotide sequence encoding amino acids 126-133, 341-345, 359-363 or 396-404 of SEQ ID:No.2.
Dependencies are inferred from the claim text.