Nucleic acids encoding human NIK protein
AssigneeTularik Inc.
InventorsMike Rothe, Lin Wu
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Abstract
The invention provides methods and compositions relating to a novel kinase, NIK, involved in NF.kappa.B activation. The polypeptides may be produced recombinantly from transformed host cells from the disclosed NIK encoding nucleic acids or purified from human cells. The invention provides isolated NIK hybridization probes and primers capable of specifically hybridizing with the disclosed NIK genes, NIK-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
Claims15
A probe, vector or recombinant nucleic acid comprising the sequence set forth as SEQ ID NO:
- 1.
A probe, vertor or recombinant nucleic acid comprising at least 24 consecutive nucleotides of SEQ ID NO:
- 1, which consecutive nucleotides comprise nucleotides 72-75 of the sequence set forth as SEQ ID NO:1.
A probe, vector or recombinant nucleic acid encoding a polypeptide comprising the amnino acid sequence set forth as SEQ ID NO:2.
A probe, vector or recombinant nucleic acid encoding a polypeptide comprising at least 10 consecutive amino acid residues of the amino acid sequence set forth as SEQ ID NO:2, which consecutive amino acid residues comprise the amino acid residue 25 of SEQ ID NO:2.
Dependencies are inferred from the claim text.