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AssigneeImmuLogic Pharmaceutical Corporation
InventorsJay P. Morgenstern, Andrzej Konieczny, Christine B. Bizinkauskas, Andrew W. Brauer
Estimating the term…
Isolated nucleic acids encoding allergens of Canis familiaris, Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of peptides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.
An isolated peptide of dog dander allergen Can f II, produced in a host cell transformed with DNA having a nucleotide sequence shown in FIG. 18 (SEQ ID NO:
An isolated peptide of dog dander allergen Can f II, said peptide having an amino acid sequence shown in FIG. 18 (SEQ ID NO:
An isolated peptide having at least one T cell epitope recognized by a T cell receptor specific for dog dander allergen Can f II, said peptide being encoded by a nucleotide sequence shown in FIG. 18 (SEQ ID NO:
An isolated peptide having at least one T cell epitope recognized by a T cell receptor specific for dog dander allergen Can f II, encoded by a nucleotide sequence in the coding region of the nucleotide sequence shown in FIG. 18 (SEQ ID NO:
An isolated peptide of dog dander allergen Can f II produced in a host cell transformed with DNA consisting of bases 195-734 of the nucleotide sequence shown in FIG. 18 (SEQ ID NO:
An isolated peptide having at least one T cell epitope recognized by a T cell receptor specific for dog dander allergen Can f II, said peptide consisting of a portion of the amino acid sequence shown in FIG. 18 (SEQ ID NO:
A composition suitable for pharmaceutical administration comprising at least one peptide comprising amino acid residues 1-161 of FIG. 18 (SEQ ID NO:
A method of selecting a peptide recognized by a T cell receptor specific for dog dander allergen Can f II, comprising:
Dependencies are inferred from the claim text.