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AssigneeUniversidade De Santiago De Compostela
InventorsPilar Calvo Salve, Maria Jose Alonso Fernandez, Carmen Remunan Lopez, Jose Luis Vila Jato
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Stabilization of colloidal systems through the formation of lipid-polyssacharide complexes. Development of a procedure for the preparation of colloidal systems involving a combination of two ingredients: a water soluble and positively charged polyssacharide and a negatively charged phospholipid. Colloidal systems (submicron emulsions and polymeric nanoparticles and nanocapsules) are stabilized through the formation, at the interface, of an ionic complex: aminopolyssachride-phospholipid. These colloidal systems are characterized by their positive charge and their improved stability. Furthermore, they can be freeze-dried, stored in a dry state and hydrated when required. They can be interesting systems for the administration of drugs by the oral, transdermal, ocular, nasal and vaginal routes of administration. In addition, they can be of interest for cosmetic use.
A process for the preparation of a colloidal system having a size less than 1 micron suitable for delivery of an active material, said system comprising a coated member selected from the group consisting of nanodroplet, nanocapsule and nanoparticle, comprising the steps of
A colloidal system having a size less than 1 micron comprising a coated member selected from the group consisting of nanodroplet, nanocapsule and nanoparticle comprising a hydrophobic polymer or oil and having a surface coating which is the ionic reaction product of a negatively charged phospholipid and a cationic aminopolyssacharide selected from the group consisting of chitin and chitosan, said member having a positive surface charge.
Dependencies are inferred from the claim text.