Products and processes for the treatment of the alimentary canal
AssigneeTillotts Pharma AG
InventorsJohn Rhodes, Brian Kenneth Evans
Life of this patent
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Abstract
Complexes of bismuth, e.g. bismuth salts, and polyacrylate, e.g. carbomer, are discloses which may be incorporated into pharmaceutical compositions for oral, oral delayed-release, and rectal administration. The complexes may be combined with an antibiotic, such as tetracycline, and an antiprotozoal agent, e.g. Metronidazole, for use in the treatment of Helicobacter pylori infection. The treatment of inflammatory bowel disease using bismuth/polyacrylate complexes, or other bismuth preparations, is also described.
Claims21
A water soluble complex of bismuth with a polyacrylate.
A process for the preparation of a water-soluble complex of bismuth and a polyacrylate comprising reacting a bismuth-containing compound with a polyacrylate in a liquid phase.
A method of treating inflammatory bowel disease which comprises the step of administering a pharmaceutically effective amount of a water-soluble complex of bismuth with a polyacrylate either orally in a delayed or sustained-release dosage form, or rectally.
Dependencies are inferred from the claim text.