Treatment of proliferative disorders, metastasaes, and drug resistant tumors with vanadate compounds and derivatives or analogues thereof
AssigneeMount Sinai Hospital
InventorTony Cruz
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Abstract
The present invention relates to the use of vanadate compounds, or analogues of vanadate compounds, as antiproliferative and anti-metastatic agents, and to compositions containing vanadate compounds adapted for such use in methods for the treatment of proliferative disorders, methods of reducing the ability of a tumor to metastasize and methods for treating drug resistant tumors.
Claims10
A method for reducing or inhibiting the growth of a drug resistant tumor in a patient comprising administering to the patient a pharmaceutical composition consisting essentially of an amount of a vanadate or vanadyl compound effective to reduce or inhibit the growth of the drug resistant tumor and a pharmaceutically acceptable vehicle.
A method for reducing metastases in a patient comprising administering to the patient a pharmaceutical composition consisting essentially of an amount of a vanadate or vanadyl compound effective to reduce metastases and a pharmaceutically acceptable vehicle.
A pharmaceutical composition for use in reducing tumor cell proliferation, consisting essentially of a vanadate or vanadyl compound and at least one antioxidant, and one or more of a pharmaceutically acceptable carrier, diluent, or excipient wherein the pharmaceutical composition is adapted for administration to a patient in vivo, and the vanadate or vanadyl compound is present in an amount which provides a serum concentration of the compound in the patient of at least 5 .mu.M.
Dependencies are inferred from the claim text.