Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
AssigneeAlza Corporation
InventorsTerry L. Burkoth, Lina T. Taskovich, Russell D. Beste, Robert M. Gale, Eun Soo Lee, Richard D. Hamlin, Su LL Yum
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Abstract
Compositions, devices, and methods for transdermal administration of an active agent are disclosed using a novel dual permeation enhancer mixture comprising lauryl acetate and a monoglyceride, preferably glycerol monolaurate. The dual permeation enhancer mixture comprising lauryl acetate is a potent permeation enhancer and provides stable systems which are more readily characterized.
Claims19
A pressure sensitive adhesive composition for the transdermal administration of a therapeutic agent comprising, by weight:
- (a) 0.1-30% of a therapeutic agent,
- (b) 30-90% of a hydrophobic pressure sensitive adhesive,
- (c) 1-40% of a permeation enhancer capable of plasticizing the hydrophobic pressure sensitive adhesive, said permeation enhancer comprising lauryl acetate and a monoglyceride.
A device for the transdermal administration of a therapeutic agent at a therapeutically effective rate comprising:
- (a) a backing layer, and
- (b) an agent reservoir matrix on the skin contacting surface of the backing layer comprising a polymeric blend comprising, by weight:
- (i) 40-90% of a hydrophobic pressure sensitive adhesive,
- (ii) 0.1-30% therapeutic agent, and
- (iii) a permeation enhancer comprising 1-30% of a monoglyceride and 1-30% lauryl acetate.
Dependencies are inferred from the claim text.