Recombinant human cytomegalovirus having a US2 deletion
AssigneeAmerican Cyanamid Company
InventorThomas R. Jones
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Abstract
Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down-regulation of cell surface expression of MHC class I. A recombinant mutant HCMV which fails to down-regulate class I heavy chain expression is described. A method of controlling down-regulation of MHC class I expression in a cytomegalovirus infected cell, a pharmaceutical composition, a vaccine composition, a method of preventing or reducing susceptibility to acute cytomegalovirus in an individual, and a virus based gene therapy vector are also described.
Claims6
A method of producing a recombinant human cytomegalovirus comprising the step of deleting a gene sequence which consists of the gene sequence encoding open reading frame US2 from the genome of a human cytomegalovirus.
A recombinant human cytomegalovirus comprising a genome having a deletion of the gene sequence encoding open reading frame US2, wherein no other gene sequence has been deleted.
Dependencies are inferred from the claim text.