Alvac poxvirus-rabies compositions and combination compositions and uses
AssigneeVirogenetics Corporation
InventorsEnzo Paoletti, Joanne Maki
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Abstract
Attenuated recombinant viruses containing DNA encoding a rabies virus antigen in a "cocktail" or combination or multivalent compositions well as methods for making and using the compositions, expression products therefrom, and antibodies generated, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The compositions and products therefrom and antibodies generated have several preventive, therapeutic and diagnostic uses.
Claims35
A composition for inducing an immunological response comprising:
- (i) a recombinant ALVAC canarypox virus comprising exogenous DNA encoding at least one rabies virus antigen or a recombinant poxvirus having all of the identifying characteristics of ALVAC comprising exogenous DNA encoding at least one rabies virus antigen, wherein the at least one rabies virus antigen is expressed in vivo as a first antigen;
- and
- (ii) at least one second antigen;
- and optionally
- (iii) a suitable carrier.
A composition for inducing an immunological response comprising:
- (i) as a first antigen at least one rabies virus antigen from in vitro expression thereof by a recombinant ALVAC canarypox virus comprising exogenous DNA encoding the at least one rabies virus antigen or a recombinant poxvirus having all of the identifying characteristics of ALVAC comprising exogenous DNA encoding the at least one rabies virus antigen;
- and
- (ii) at least one second antigen;
- and optionally
- (iii) a suitable carrier.
A composition comprising (i) any one of Canine Distemper Virus antigen, Canine Adenovirus Type 2 antigen, Canine Coronavirus antigen, Canine Parainfluenza antigen, and Canine Parvovirus antigen;
- and (ii) vCP65.
A composition comprising (i) any one of Canine Distemper Virus antigen, Canine Adenovirus Type 2 antigen, Canine Coronavirus antigen, Canine Parainfluenza antigen, and Canine Parvovirus antigen;
- and (ii) a rabies antigen from in vitro expression thereof by vCP65.
Dependencies are inferred from the claim text.