Growth hormone potentiating molecules
AssigneeBiotechnology & Biological Sciences Research Council
InventorsAndrew Thomas Holder, James Beattie
Life of this patent
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Abstract
Antigenic molecules cause antibodies to be raised against at least some of the 91 to 102 region of a natural growth hormone when parenterally administered in vivo. The molecules can include portions of the 91 to 102 region, particularly the 94 to 98 region. The antibodies are believed to bind to growth hormone on administration and enhance its effect.
Claims6
An antigenic molecule consisting of the amino acid sequence selected from:
- Xaa Arg Xaa Xaa Thr Xaa Xaa (SEQ ID No:36)
- where
- Xaa position 1 is Ser, Cys, Asp or Glu
- Xaa position 3 is Val or Ile
- Xaa position 4 is Phe, Trp, Tyr or Cys
- Xaa at position 6 is Asn or His
- Xaa position 7 is Set, Ala or Gly.
An antigenic molecule consisting of the amino acid sequence:
- QFLSRVFINSLV (SEQ ID No:1).
An antigenic molecule consisting of the amino acid sequence:
- SRVFINS (SEQ ID No:25).
An antigenic molecule consisting of an amino acid sequence selected from
- Xaa Arg Xaa Phe Thr Asn Ser (SEQ ID No:37),
- where
- Xaa position 1 is Ser, Cys, Asp or Glu
- Xaa position 3 is Val or Ile.
A conjugate molecule comprising an antigenic molecule selected from the group consisting of the amino acid sequence:
- (b) QFLSRVFTNSLV (SEQ ID No;1);
- (c) SRVFT (SEQ ID No:10);
- (d) SRVFTNS (SEQ ID No:25);
- and, linked to an inert protein.
Dependencies are inferred from the claim text.