Immunotherapy composition and method
AssigneePharmagenesis, Inc.
InventorsTien-Wen Tao Wiedmann, Jian Wang, Nathan B. Pliam, Hank C. K. Wuh
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Abstract
A composition for use in immunosuppression therapy is disclosed. The composition includes an immunosuppressant drug, such as cyclosporin A, and an ethanol extract of the root xylem of Tripterygium wilfordii. The extract is effective alone, or in combination with such an immunosuppressant, in the treatment of transplantation rejection. Also disclosed is a method of immunosuppression that includes administering to a subject a pharmaceutically effective amount of an immunosuppressant drug and an extract of the type above, in an amount effective to potentiate the action of the drug.
Claims7
An immunosuppression therapy method for use in a mammalian subject, comprising
- administering to the subject (i) a pharmaceutically effective amount of an immunosuppressant drug selected from the group consisting of cyclosporin A, FK506, azathioprine, rapamycin, mycophenolic acid, and a glucocorticoid;
- and (ii) an ethanol extract from the root xylem of Tripterygium wilfordii, in an amount effective to potentiate the immunosuppressive effect of the immunosuppressant drug.
Dependencies are inferred from the claim text.