Method of treating rheumatoid arthritis with type II collagen
AssigneeAutoimmune, Inc.
InventorsHoward L. Weiner, David E. Trentham
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Abstract
The present invention is directed to a method and pharmaceutical formulations for the treatment of autoimmune arthritis and animal models therefore in mammals, including humans, by the oral, enteral or by-inhalation administration of whole collagen protein or biologically active peptide fragments of collagen.
Claims25
A method for treating rheumatoid arthritis by suppressing an autoimmune response associated with said arthritis comprising orally or enterally administering to a human in need of treatment Type II collagen or a fragment thereof in an amount effective and for a period of time sufficient to suppress said response.
A method for treating rheumatoid arthritis in a human in need of treatment comprising orally or enterally administering to said human type II collagen or a fragment thereof effective to suppress autoimmune response in at least one afflicted joint of said human in an amount effective to suppress said autoimmune response.
A method for treating rheumatoid arthritis comprising orally administering to a human in need of treatment Type II collagen or a fragment thereof effective to decrease at least one clinical symptom of said arthritis in an amount effective and for a period of time sufficient to decrease said at least one clinical symptom.
A method for treating rheumatoid arthritis comprising orally administering to a human in need of treatment chicken Type II collagen in an amount effective and for a period of time sufficient to decrease at least one clinical symptom of said arthritis.
A method for treating rheumatoid arthritis comprising orally administering to a human in need of treatment a therapeutic agent consisting essentially of Type II collagen or a fragment effective to decrease at least one clinical symptom of said arthritis thereof, in an amount effective and for a period of time sufficient to decrease said at least one clinical symptom.
Dependencies are inferred from the claim text.