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US 5,843,440 AGranted
Cellular and serum protein anchors for modulating pharmacokinetics
AssigneeRedCell, Canada, Inc.
InventorsPhilippe Pouletty, Christine Pouletty
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AssigneeRedCell, Canada, Inc.
InventorsPhilippe Pouletty, Christine Pouletty
Estimating the term…
Novel bifunctional reagents useful in reducing the biological effect of an undesirable blood-borne agent are provided. The reagents comprise conjugates of a first binding member specific for a blood-borne agent having a detrimental biological activity in a mammalina host, such as a growth factor, coagulation factor, enzyme, toxin, drug of abuse, microbe, autoreactive immune cell, infected or tumorous cell, joined to an second binding member specific for an anchor, where the anchor is a long-lived blood component, including cells, such as a erythrocyte, platelet or endothelial cell and serum proteins, such as albumin, ferritin, or steroid binding proteins. These conjugates find therapeutic use by coupling the agent and the blood component and thereby reducing the biological activity or effective concentration of free agent, modulating the volume of distribution of the agent, targeting the agent to sites of enhanced immune response, or facilitating agent clearance from the bloodstream.
A method for extending the lifetime of a conjugate in the blood stream of a host, wherein said conjugate is capable of binding to a physiologically active target agent, said method comprising;
A method for extending the lifetime of a conjugate in the blood stream of a host, wherein said conjugate is capable of binding to a drug, said method comprising
A method for extending the lifetime of a conjugate in the blood stream of a host, wherein said conjugate is capable of binding to cocaine, said method comprising;
Dependencies are inferred from the claim text.