US 5,843,438 AGranted

Peripheralization of hematopoietic stem cells

AssigneeThe Board of Regents of the University of Washington

InventorThalia Papayannopoulou

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Abstract

The invention relates to in vivo peripheralization of CD34.sup.+ cells by administering anti-VLA-4 antibodies or anti-VCAM-1 antibodies.

Claims14

Dependent claims

A method of peripheralizing CD34.sup.+ cells in vivo comprising the step of administering an anti-VLA-4 antibody or an anti-VCAM-1 antibody which blocks the binding of VLA-4 antigen on the surface of the CD34.sup.+ cells to VCAM or fibronectin.

Dependencies are inferred from the claim text.

Facts

Application: 08/436,339Filed 13 Jul 1995 · continuation in part
Priority: 13 Nov 1992
Granted: 1 Dec 1998
Term ends: Not estimatedThe source records don’t support an estimate.

Classification22 codes

C07K 16/2842
Against the integrin superfamily: against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
A61K 31/505
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: pyrimidines; Hydrogenated…
A61K 35/14
Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically…:…
A61K 38/193
Cytokines; Lymphokines; Interferons: colony stimulating factors [CSF]

Family

Serial977,702Parent of this continuation-in-part · filed 13 Nov 1992
US 5,843,438 AThis patent

From the US filing history. Foreign family members aren’t listed.

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