Back to results
US 5,843,437 AGranted
A82846 antibiotics
AssigneeEli Lilly and Company
InventorsRobert L. Hamill, James A. Mabe, David F. Mahoney, Walter M. Nakatsukasa, Raymond C. Yao
Life of this patent
Estimating the term…
Abstract
New glycopeptide antibiotic A82846, comprising A82846A, A82846B and A82846C, is produced by Nocardia orientalis strains NRRL 18098, NRRL 18099 and NRRL 18100. The A82846 antibiotics have activity against Gram-positive bacteria comparable to that of vancomycin.
Claims33
Antibiotic A82846A, which has the following characteristics:
- Molecular Weight:
- 1556
- Empirical Formula:
- C.sub.73 H.sub.89 N.sub.10 O.sub.26 Cl
- FAB-MS (thioglycerol):
- FIG. 4
- UV (H.sub.2 O) .lambda.max:
- 281 nm (.epsilon. 5,052)
- IR (KBr):
- FIG. 1
- NMR (CD.sub.3).sub.2 SO!:
- FIG. 7
- pKa (H.sub.2 O):
- 4.7, 9.5
- (66% DMF):
- 5.5, 6.8, 7.9, 9.4, 12.3
- Contains:
- aspartic acid and 4-epi-vancosamine;
- or a salt thereof.
16 more elements
Antibiotic A82846B, which has the following characteristics:
- Molecular Weight:
- 1590
- Empirical Formula:
- C.sub.73 H.sub.88 N.sub.10 O.sub.26 Cl.sub.2
- FAB-MS (thioglycerol):
- FIG. 5
- UV (H.sub.2 O) .lambda.max:
- 280 nm (.epsilon. 5,192)
- IR (KBr):
- FIG. 2
- NMR (CD.sub.3).sub.2 SO!:
- FIG. 8
- pKa (H.sub.2 O):
- 4.65, 9.5
- Contains:
- aspartic acid and 4-epi-vancosamine;
- or a salt thereof.
14 more elements
Antibiotic A82846C, which has the following characteristics:
- Molecular weight:
- 1522
- Empirical Formula:
- C.sub.73 H.sub.90 N.sub.10 O.sub.26
- FAB-MS (thioglycerol):
- FIG. 6
- UV (H.sub.2 O) .lambda.max:
- 280 nm (.epsilon. 5,198)
- IR (KBr):
- FIG. 3
- NMR (CD.sub.3).sub.2 SO!:
- FIG. 9
- pKa (H.sub.2 O):
- 4.6, 9.4
- Contains:
- aspartic acid and 4-epi-vancosamine;
- or a salt thereof.
14 more elements
Dependencies are inferred from the claim text.