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US 5,843,426 AGranted
Salmonella vaccines
AssigneesThe General Hospital Corporation, President and Fellows of Harvard College
InventorsSamuel I. Miller, John J. Mekalanos
Life of this patent
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Abstract
The invention features a Salmonella cell the virulence of which is attenuated by a deletion of a portion of the PhoQ gene and Salmonella cells having a deletion of the PhoQ gene and a deletion of the PhoP gene. The invention also features vaccines comprising such bacteria.
Claims1
A vaccine comprising a Salmonella typhi Ty800 cell, said cell comprising a mutation in the phoQ gene, wherein said mutation attenuates virulence and does not result in the insertion of an antibiotic resistance gene into said phoQ gene.
Dependencies are inferred from the claim text.