Diagnostic agent for hypoxia or mitochondrial dysfunction comprising radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative
AssigneeNihon Medi-Physics Co., Ltd.
InventorsYasuhisa Fujibayashi, Akira Yokoyama
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Abstract
A diagnostic agent for hypoxia or mitochondrial dysfunction is disclosed, comprising a radioactive copper complex of a dithiosemicarbazone derivative or a radioactive copper complex of a diamine diol schiff base derivative. This agent has good transferability to the target tissue, reduction reaction affinity at a hypoxic site, high stability in a non-target site and rapidly disappears.
Claims11
A diagnostic agent for hypoxia or mitochondrial dysfunction comprising a radioactive copper complex of a dithiosemicarbazone derivative represented by the following formula:
- ##STR4## wherein each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently represents hydrogen, alkyl or alkoxy, with the proviso that R.sub.1 and R.sub.2 are the same, and Cu represents a radioactive isotope Cu-62, or a radioactive copper complex of a diamine diol schiff base derivative represented by the following formulae:
- ##STR5## wherein each of R.sub.5, R.sub.6, and R.sub.7 independently represents hydrogen, alkyl or alkoxy, and Cu represents a radioactive isotope Cu-62, or ##STR6## wherein the R.sub.8 represents hydrogen or alkyl, and Cu represents a radioactive isotope Cu-62.
A diagnostic agent for hypoxia or mitochondrial dysfunction comprising a radioactive copper complex of a dithiosemicarbazone derivative represented by the following formula:
- ##STR7## wherein each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently represents hydrogen, alkyl or alkoxy, with the proviso that R.sub.1 and R.sub.2 are the same, and Cu represents a radioactive isotope Cu-62.
A diagnostic agent for hypoxia or mitochondrial dysfunction comprising a radioactive copper complex of a diamine diol schiff base derivative represented by the following formula:
- ##STR8## wherein each of R.sub.5, R.sub.6, and R.sub.7 independently represents hydrogen, alkyl or alkoxy, and Cu represents a radioactive isotope Cu-62.
A diagnostic agent for hypoxia or mitochondrial dysfunction comprising a radioactive copper complex of a diamine diol schiff base derivative represented by the following formula:
- ##STR9## wherein the R.sub.8 represents hydrogen or alkyl, and Cu represents a radioactive isotope Cu-62.
Dependencies are inferred from the claim text.