Cytotoxic therapy for graft rejection
AssigneeImmunomedics, Inc.
InventorMilton David Goldenberg
Life of this patent
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Abstract
Anticancer, antimicrobial and autoimmune disease, and anti-organ rejection therapy using cytotoxic agents is improved using cytokines to prevent, mitigate or reverse adverse radiation-induced or drug-induced toxicity, especially to hematopoietic cells. Cytotoxic agents can include radioisotopes, drugs, toxins and even unconjugated cytotoxic antibodies. A preferred cytokine is IL-1. Higher doses of cytotoxic agents can be administered and tolerated by the patient and dose-limiting marrow toxicity can be prevented, palliated or reversed using adjunct cytokine therapy.
Claims31
In a method of therapy of graft rejection, wherein a human patient undergoing a tissue or organ transplant is treated with a therapeutic amount of a cytotoxic agent which also produces hematopoietic or myeloid toxicity,
- the improvement which comprises administering to said patient an amount of a differentiation/maturation-inducing cytokine, prior to, simultaneously with or subsequent to exposure to said cytotoxic agent, wherein said amount is effective for substantially preventing, mitigating or reversing said hematopoietic or myeloid toxicity.
Dependencies are inferred from the claim text.