Method to produce highly pure eicosapentaenoic acid or its ester
AssigneeNippon Suisan Kaisha, Ltd.
InventorsKiyomi Furihata, Kazuhiko Hata
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Abstract
A mixture of fatty acids or their esters derived from natural oils and fats including eicosapentaenoic acids or their derivatives is precision distilled under a high vacuum using a plurality of distillation columns, three distillation columns or more in particular, in order to acquire a fraction consisting mainly of fatty acids of carbon number 20 or their esters, which is then subjected to a column chromatography with a reversed-phase distribution system. Eicosapentaenoic acids or their esters, which is useful for preventing or treating thrombus, with a purity as high as 99% and above and with a recovery rate 55% or above, is produced.
Claims5
A method of producing highly pure eicosapentaenoic acids or their ester wherein a mixture of fatty acids or their esters derived from natural oils and fats containing eicosapentaenoic acids or their derivatives is precision distilled in a plurality of distillation columns under a high vacuum to acquire a fraction consisting mainly of fatty acids of carbon number 20 or their esters, followed by subjecting the fraction to the column chromatography with a reversed-phase distribution system for partition refining.
A method of producing eicosapentaenoic acids or their esters at a purity of 99% and above, which consists of the step of subjecting a mixture of fatty acids or their esters derived from natural oils and fats to precision distillation in a plurality of distillation columns of three or more under a reduced pressure of 10 Torr or below and a temperature of 210.degree. C. or below to obtain a fraction consisting mainly of fatty acids of a carbon number of 20 or their esters, followed by the step of subjecting the fraction to column chromatography with a reversed-phase distribution system to partition refine the fatty acids so as to separate and recover eicosapentaenoic acids or their esters from said fraction at a purity of 99% and above.
Dependencies are inferred from the claim text.