Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility
AssigneeTakeda Chemical Industries, Ltd.
InventorsYoshiaki Uda, Takako Yamauchi, Yasushi Nakagawa, Toshihiro Ishiguro, Masahide Oka, Takamasa Yamaguchi, Ikuo Nogami
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Abstract
A composition is disclosed comprising a water-insoluble or slightly water-soluble compound and a branched cyclodextrin-carboxylic acid. The branched cyclodextrin-carboxylic acid significantly increases the water-solubility of the compound. Also disclosed is a method of enhancing water-solubility of the compound.
Claims6
A composition comprising a water-insoluble or slightly water-soluble compound and a branched cyclodextrin-carboxylic acid, said branched cyclodextrin-carboxylic acid being selected from the group consisting of 6-O-cyclomaltoheptaosyl-(6.fwdarw.1)-.alpha.-D-glucosyl-(4.fwdarw.1)-O-.al pha.-D-glucuronic acid, 6-O-cyclomaltoheptaosyl-(6.fwdarw.1)-.alpha.-D-glucuronic acid and 2-hydroxy-3-O-(6-cyclomaltoheptaosyl)propionic acid.
A composition comprising a water-insoluble or slightly water-soluble compound having a water solubility of not more than 10 mg/ml and a branched cyclodextrin-carboxylic acid, said branched cyclodextrin-carboxylic acid having as the branched moiety, (1) a group containing 1 to 3 glucosyl groups such that at least one hydroxymethyl group of the glucosyl groups in the branched moiety has been oxidized to a carboxyl group or (2) 2-carboxy-2-hydroxyethyl, at the 6-O-position of at least one glucose unit of the cyclodextrin ring.
A composition comprising a water-insoluble or slightly water-soluble compound and a branched cyclodextrin-carboxylic acid which is produced microbiologically, said branched cyclodextrin-carboxylic acid having as the branched moiety, (1) a group containing 1 to 3 glucosyl groups such that at least one hydroxymethyl group of the glucosyl groups in the branched moiety has been oxidized to a carboxyl group or (2) 2-carboxy-2-hydroxyethyl, at the 6-O-position of at least one glucose unit of the cyclodextrin ring.
Dependencies are inferred from the claim text.