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US 5,840,677 AGranted
Boronic acid or borinic acid derivatives as enzyme stabilizers
AssigneesNovo Nordisk A/S, Borax Consolidated Ltd.
InventorsLone Kierstein Nielsen, Allison Deane-Wray
Life of this patent
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Abstract
The invention relates to a detergent composition comprising an enzyme and a boronic acid or borinic acid derivative which acts as a stabilizer for the enzyme in detergent compositions. Specific boronic acid inhibiters include benzofuran substituted boronic acids.
Claims10
A liquid composition comprising an enzyme and a boronic acid derivative enzyme stabilizer or borinic acid derivative enzyme stabilizer of the following formula:
- ##STR3## where R.sub.1 is (a) a substituted fused aromatic ring structure containing 14 or 18 carbon atoms in the ring;
- (b) a substituted monocyclic heterocyclic ring structure containing up to 17 carbon atoms in the ring;
- (c) a substituted fused aromatic heterocyclic ring structure containing up to 17 carbon atoms in the ring;
- (d) a substituted monocyclic quinonone ring structure containing up to 18 carbon atoms in the ring;
- (e) a substituted fused quinonone ring structure containing up to 18 carbon atoms in the ring;
- wherein
- R.sub.2 has the formula:
- ##STR4## where X is the same or different and selected from hydrogen, C.sub.1 -C.sub.6 alkyl, substituted C.sub.1 -C.sub.6 alkyl, aryl, substituted aryl, hydroxy, hydroxyl derivative, halogen, amine, alkylated amine, amine derivative, nitro, thiol, thiol derivative, aldehyde, acid, acid salt, ester, sulfonate or phosphonate, and o, p and q may each be 0, 1, or 2;
- n and m may each be 0 or 1;
- R.sub.1 and R.sub.3 are independently one of a hydroxyl group, a substituted monocyclic ring structure, or a substituted dicyclic aromatic ring structure.
7 more elements
Dependencies are inferred from the claim text.