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US 5,840,338 AGranted
Loading of biologically active solutes into polymer gels
OwnerEric J. Roos, Matthew E. Schillerinventors
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Abstract
Polymer gel networks loaded with biologically active solutes in a manner that solute activity is maintained and protected from thermal and/or chemical degradation while in the gel network are provided. The invention also provides for effects of modulating parameters for loading safe responsive gel networks using loading solutions containing phase separating polymers.
Claims29
A method of loading a biologically active solute into a crosslinked polymer gel network, comprising:
- selecting the crosslinked polymer gel network;
- forming a loading polymer solution, the loading polymer solution comprising a loading polymer, a salt and the biologically active solute, the lading polymer solution having a pH above the isoelectric point of the biologically active solute;
- and
- contacting the crosslinked polymer gel network with the loading polymer solution under conditions sufficient for at least a portion of the loading polymer solution to partition into the gel network and for at the biologically active solute to retain activity while in the gel network.
1 more element
A method of loading a biologically active solute into a crosslinked polymer gel network, comprising:
- selecting the crosslinked polymer gel network;
- forming a loading polymer solution, the loading polymer solution comprising a loading polymer, a salt and the biologically active solute, the loading polymer solution having a pH below the isoelectric point of the biologically active solute;
- and
- contacting the crosslinked polymer gel network with the loading polymer solution under conditions sufficient for at least a portion of the loading polymer solution to partition into the gel network and for the biologically active solute to retain activity while in the gel network.
1 more element
Dependencies are inferred from the claim text.