Treatment of bacterially-induced inflammatory diseases
AssigneeBristol-Myers Squibb Company
InventorRichard P. Darveau
Life of this patent
Estimating the term…
Abstract
The lipopolysaccharide of bacteria associated with chronic inflammatory diseases is unable to induce expression of leukocyte adhesion molecules, or selectins, on endothelial cells, and is also capable of inhibiting the induction of selectin expression by bacteria normally associated with acute endotoxin disease. New approaches to treatment of these diseases, and the diagnosis of susceptibility to chronic bacterial-associated inflammatory diseases, are provided.
Claims13
A method for modulating the progression of periodontal disease in a mammal, which comprises:
- administering to the mammal a compound which inhibits the ability of Porphyromonas gingivalis to inhibit the extravasation of leukocytes from the vascular endothelium to gingival tissues.
A composition for inhibiting gram-negative bacterial infection, the composition comprising a pharmaceutical carrier and a binding polypeptide which binds to lipopolysaccharide of P. gingivalis and which inhibits the ability of said P. gingivalis lipopolysaccharide to suppress selectin expression by host endothelial cells.
Dependencies are inferred from the claim text.