Preventive or therapeutic agents for alzheimers disease a screening method of alzheimers disease and tau-protein kinase I originated from human being
AssigneeMitsubishi Chemical Corporation
InventorsAkihiko Takashima, Toshimitsu Hoshino, Kazutomo Imahori, Ken-ichi Saito, Akiko Shiratsuchi, Showbu Sato
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Abstract
A preventive or therapeutic agent for Alzheimer's disease which comprises a substance exhibiting an inhibitory action to tau-protein kinase I as an effective component is provided. A pharmaceutical composition comprising said agent and a method of inhibiting neuronal cell death in the brain are also provided.
Claims8
An antisense oligonucleotide which inhibits expression of mRNA encoding tau-protein kinase I, which oligonucleotide binds specifically to said mRNA in such a manner that it binds to at least one nucleotide of the portion of said mRNA which is complementary to SEQ. I.D. NO:
- 5 or 7.
Dependencies are inferred from the claim text.