Ingap protein involved in pancreatic islet neogenesis
AssigneeEastern Virginia Medical School of the Medical College of Hampton Roads
InventorsAaron I. Vinik, Gary L. Pittenger, Ronit Rafaeloff, Lawrence Rosenberg, William P. Duguid
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Abstract
Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.
Claims24
A preparation of a naturally occurring mammalian islet neogenesis associated protein (INGAP protein) substantially free of other mammalian proteins.
A preparation of a polypeptide which comprises a sequence of at least 15 consecutive amino acids of a naturally occuring mammalian islet neogenesis associated protein (INGAP protein), wherein said polypeptide has immunogenic activity.
A preparation of an islet eogenesis associated protein (INGAP protein) of a mammal substantially purified from other proteins of the mammal wherein said INGAP protein is inducible upon cellophane-wrapping of pancreas of the mammal.
A pharmaceutical composition for treatment of pancreatic insufficiency, comprising:
- a naturally occuring mammalian islet neogenesis associated protein (INGAP protein) in a pharmaceutically acceptable diluent or carrier.
A pharmaceutical composition comprising:
- a preparation of a polypeptide which comprises a sequence of at least 15 consecutive amino acids of a naturally occurring mammalian islet neogenesis associated protein (INGAP protein) and a pharmaceutically acceptable diluent or carrier, wherein said polypeptide is capable of stimulating .beta. cell regeneration of pancreatic ductal cells.
Dependencies are inferred from the claim text.