Hexa-cyclic compound
AssigneesDaiichi Pharmaceutical Co., Ltd., Kabushiki Kaisha Yakult Honsha
InventorsHirofumi Terasawa, Akio Ejima, Satoru Ohsuki, Kouichi Uoto
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Abstract
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.
Claims15
A method of treating a tumor in a subject in need of treatment which comprises administering to said subject an effective amount of a hexa-cyclic compound:
- (9S)-1-Amino-9-ethyl-5-fluoro-2,3-dihydro-9-hydroxy-4-methyl-1H, 12H-benzo-de!pyrano3',4':
- 6,7!indolizino1,2-b!quinoline-10,13(9H, 15H)-dione hydrochloride or
- (9S)-1 -Amino-9-ethyl-5-fluoro-2,3-dihydro-9-hydroxy-4-methyl-1H, 12H-benzo-de!pyrano3',4':
- 6,7!indolizino1,2-b!quinoline-10,13(9H, 15H)-dione methanesulfonate,
- wherein said tumor is associated with a cancer selected from the group consisting of lung cancer, gastric cancer, colon cancer, stomach cancer, esophageal cancer, ovarian cancer, cervical cancer, breast cancer, hepatoma, leukemia, lymphoma, renal cancer and testicular cancer.
Dependencies are inferred from the claim text.