Pharmaceutical composition containing sialic acid derivatives
AssigneeTaiyo Kagaku Co., Ltd.
InventorsMamoru Koketsu, Masakazu Nishizono, Teruhiko Nitoda, Yuko Enoki, Hiroshi Kawanami, Lekh Raj Juneja
Life of this patent
Estimating the term…
Abstract
The present invention is a pharmaceutical composition used as an antiviral agent, a diarrheal remedy, an antiulcer agent, an anti-inflammatory agent, an anti-allergic agent and an agent for promoting the proliferation of Bifidobacteria, characterized by containing a sialic acid derivative as an active ingredient. The method for producing a sialic acid derivative of the present invention is characterized in that an almond or apricot seed is added to an avian egg yolk, by which the desired product can easily be obtained in a high yield.
Claims27
A pharmaceutical composition characterized by containing as an active ingredient a sialic acid derivative represented by the general formula (1) or (2) below:
- ##STR15## wherein R.sup.1 represents a glycopeptide residue;
- and X.sup.1 and X.sup.2, which may be identical or different, represent NeuAc(.alpha.2,6)Gal(.beta.1,4)GlcNAc(.beta.1,2)-, Gal(.beta.1,4)GlcNAc(.beta.1,2)-, or GlcNAc(.beta.1,2)-, provided that at least one of X.sup.1 and X.sup.2 represents NeuAc(.alpha.2,6)Gal(.beta.1,4)Glc NAc(.beta.1,2)-;
- ##STR16## wherein R.sup.2 and R.sup.3, which may be identical or different, represent a hydrogen atom or a linear, branched or cyclic, saturated or unsaturated acyl group having 1 to 30 carbon atoms;
- n is an integer of 1 to 20;
- and X.sup.3 represents a sialic acid derivative residue or a sialyloligosaccharide derivative residue represented by the general formula (3) below:
- ##STR17## wherein X.sup.4 and X.sup.5, which may be identical or different, represent NeuAc(.alpha.2,6)Gal(.beta.1,4)GlcNAc(.beta.1,2)-, Gal(.beta.1,4)GlcNAc(.beta.1,2)- or GlcNAc(.beta.1,2)-, provided that at least one of X.sup.4 and X.sup.5 represents NeuAc(.alpha.2,6)Gal(.beta.1,4)Glc NAc(.beta.1,2)-;
- and Y represents a sugar residue.
A method for producing a sialic acid derivative represented by the following general formula (4) ##STR18## wherein R.sup.4 represents a sugar residue;
- X.sup.1 and X.sup.2, which may be identical or different, represent NeuAc(.alpha.2,6)Gal(.beta.1,4)GlcNAc(.beta.1,2)-, Gal(.beta.1,4)GlcNAc(.beta.1,2)- or GlcNAc(.beta.1,2)-, provided that at least one of X.sup.1 and X.sup.2 represents NeuAc(.alpha.2,6)Gal(.beta.1,4)GlcNAc(.beta.1,2)- comprising the steps of:
- (a) adding water or brine selected from a potassium salt, a sodium salt and a salt capable of buffering over the range of pH 5 to 10 to avian egg yolk,
- (b) stirring and filtering the mixture obtained in step (a),
- (c) adding almond or apricot seed to the filtrate obtained in step (b),
- (d) stirring the mixture obtained in step (c),
- (e) subjecting the mixture obtained in step (d) to an anion exchange resin and carrying out elution, and
- (f) desalting the eluate obtained in step (e).
Dependencies are inferred from the claim text.