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US 5,834,279 AGranted
Methods of identifying compounds that inhibit DNA synthesis in mycobacterium tuberculosis and compositions, reagents and kits for performing the same
AssigneeThe Trustees of the University of Pennsylvania
InventorsHarvey Rubin, Fude Yang, David Avarbock, Sean Curran
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Abstract
Nucleic acid molecules that encode R2 subunit protein and topoisomerase I protein, fragments thereof, recombinant expression vectors and host cells are disclosed. Oligonucleotide molecules with nucleotide sequences complimentary to a nucleotide sequence encode R2 subunit protein and topoisomerase I protein are disclosed.
Claims18
A recombinant expression vector comprising a nucleic acid sequence that encodes the protein having the amino acid sequence of SEQ ID NO:2, SEQ ID NO:6 or SEQ ID NO:4.
An isolated nucleic acid molecule selected from the group consisting of:
- a) SEQ ID No:1,
- b) a fragment of at least 10 contiguous nucleotides from SEQ ID No:1 or from the complement of SEQ ID No:1,
- c) SEQ ID No:5,
- d) a fragment of at least 10 contiguous nucleotides from SEQ ID No:5 or from the complement of SEQ ID No:5,
- e) SEQ ID No:3, and
- f) a fragment of at least 10 contiguous nucleotides from SEQ ID No:3 or from the complement of SEQ ID No:3.
3 more elements
Dependencies are inferred from the claim text.